The ultrasonographic picture (Determine 1) is from an 11-year-old home short-haired cat with a medical historical past of lethargy and anorexia. A segmental, small intestinal wall thickening with diffuse lack of layering was famous. A superb needle aspirate (FNA) was collected and submitted for evaluation (Wright-Giemsa, 100×; Determine 2).
The submitted smear has sufficient cellularity and preservation. The background is obvious, with frequent crimson blood cells, usually clumped, just a few naked nuclei and free magenta granules. It has a predominant inhabitants of enormous, discrete cells, probably lymphoid in origin (black arrows) – these have average quantities of flippantly basophilic cytoplasm, with distinct borders, usually containing small numbers of spherical magenta granules.
Nuclei are spherical, often barely indented and irregular, paracentrally situated, with granular chromatin and small, spherical nucleoli often seen. Occasional neutrophils (crimson arrow), probably blood derived, are additionally famous.
Giant granular lymphocyte (LGL) lymphoma is a morphologically distinct type of high-grade lymphoma, continuously affecting the feline species and most frequently involving the gastrointestinal tract (particularly jejunum and ileum) and/or mesenteric lymph nodes.
Blood and/or bone marrow involvement are widespread findings on the time of the prognosis. This type of lymphoma has usually been related to unfavorable FeLV and FIV serology.
Neoplastic cells origin from a subset of intraepithelial intestinal lymphocytes and have attribute intracytoplasmic magenta or azurophilic granules, which can fluctuate in numbers and sizes. LGL cells are grouped in two main lineages based mostly on phenotype: T-cell (CD3+, CD5+, usually CD8alpha-alpha+, and infrequently CD4+) and fewer usually pure Killer, the latter unfavorable to all T-cell and B-cell markers.
Within the feline species, LGL lymphoma has a very aggressive organic behaviour with poor prognosis and is barely minimally responsive to plain lymphoma chemotherapy protocols. This differs from LGL neoplasia in people and canines, the place a predominance of indolent types has been described.
Total, the identification of LGL lymphoma in cats is vital clinically, as different types of gastrointestinal lymphoma – particularly small cell sorts – have a extra protracted course.